ISebe leMithi yeLabhoratri, iSibhedlele sabantu baseGuangxi Zhuang Autonomous Region, eNanning, eChina
Isebe lezoNyango lweLabhoratri, iSibhedlele esiManyeneyo seYunivesithi yaseShandong yeTraditional Chinese Medicine, iJinan
U-Huang Huayi, iSikolo seLabhoratri yeLabhoratri, iYunivesithi yeSizwe yezoNyango yaseYoujiang, i-Baise, i-Guangxi, i-533000, i-Mindray North America, i-Mahwah, i-New Jersey, i-07430, i-USA.
ISebe leMithi yeLabhoratri, iSibhedlele sabantu baseGuangxi Zhuang Autonomous Region, eNanning, eChina
Isebe lezoNyango lweLabhoratri, iSibhedlele esiManyeneyo seYunivesithi yaseShandong yeTraditional Chinese Medicine, iJinan
U-Huang Huayi, iSikolo seLabhoratri yeLabhoratri, iYunivesithi yeSizwe yezoNyango yaseYoujiang, i-Baise, i-Guangxi, i-533000, i-Mindray North America, i-Mahwah, i-New Jersey, i-07430, i-USA.
Sebenzisa ikhonkco elingezantsi ukuze wabelane ngoguqulelo olupheleleyo lweli nqaku kunye nabahlobo bakho kunye noogxa bakho.Funda nzulu.
Ukuze uqonde ngcono utshintsho lwe-pathological ye-COVID-19, iluncedo kulawulo lwezonyango lwesi sifo kunye nolungiselelo lwamaza obhubhane afanayo kwixesha elizayo.
Iiparamitha ze-hematological zabaguli abangama-52 be-COVID-19 abangeniswe kwizibhedlele ezichongiweyo zahlalutywa emva kwexesha elidlulileyo.Idatha yahlalutywa kusetyenziswa isoftwe yamanani ye-SPSS.
Ngaphambi kokuba unyango, i-T cell subsets, i-lymphocytes iyonke, ububanzi bokusabalalisa iiseli ezibomvu zegazi (RDW), i-eosinophils kunye ne-basophils zaziphantsi kakhulu emva kokunyanga, ngelixa izikhombisi zokuvuvukala kwe-neutrophils, i-neutrophils kunye ne-lymphocytes Umlinganiselo (NLR) kunye ne-C β-reactive protein ( Amanqanaba e-CRP) kunye neeseli ezibomvu zegazi (RBC) kunye ne-hemoglobin yehle kakhulu emva konyango.I-T cell subsets, i-lymphocytes iyonke kunye ne-basophils yezigulane ezinzima kunye nezigulana kakhulu zaziphantsi kakhulu kunezo zezigulane ezimodareyitha.I-Neutrophils, i-NLR, i-eosinophils, i-procalcitonin (i-PCT) kunye ne-CRP ziphezulu kakhulu kwizigulane ezinzima kunye nezigulana kakhulu kunezigulana ezimodareyitha.I-CD3 +, i-CD8 +, i-lymphocytes iyonke, iiplatelet, kunye ne-basophils yezigulane ezingaphezu kweminyaka engama-50 ubudala zingaphantsi kunezo zingaphantsi kweminyaka engama-50 ubudala, ngelixa i-neutrophils, i-NLR, i-CRP, i-RDW kwizigulane ezingaphezu kweminyaka engama-50 ubudala ziphezulu kunezo zingaphantsi kweminyaka engama-50 ubudala.Kwizigulane ezinzima kunye nezigulana, kukho ulungelelwaniso oluhle phakathi kwexesha leprothrombin (PT), i-alanine aminotransferase (ALT) kunye ne-aspartate aminotransferase (AST).
I-T cell subsets, i-lymphocyte count, i-RDW, i-neutrophils, i-eosinophils, i-NLR, i-CRP, i-PT, i-ALT kunye ne-AST zizalathisi ezibalulekileyo kulawulo, ngakumbi kwizigulana ezimandundu nezigula kakhulu ezine-COVID-19.
Ubhubhani ka-2019 weCoronavirus (COVID-19) obangelwe luhlobo olutsha lwe-coronavirus uqhambuke ngoDisemba ka-2019 kwaye wasasazeka ngokukhawuleza kwihlabathi liphela.I-1-3 Ekuqaleni kokuqhambuka, ugxininiso lweklinikhi lwalukubonakaliso kunye ne-epidemiology, idibaniswe ne-computed tomography kwizigulane ze-4 kunye ne-5, kwaye emva koko kufunyaniswe iziphumo ezilungileyo ze-nucleotide amplification.Nangona kunjalo, ukwenzakala okuhlukeneyo kwe-pathological kwafunyanwa kamva kwizitho ezahlukeneyo.6-9 Ubungqina obuninzi nangakumbi bubonisa ukuba utshintsho lwe-pathophysiological lwe-COVID-19 luntsokothile.Uhlaselo lwentsholongwane lubangela umonakalo wamalungu amaninzi kwaye amajoni omzimba asabela ngokugqithisileyo.Ukunyuka kwe-serum kunye ne-alveolar cytokines kunye neeprotheni zokuphendula ezivuthayo ziye zabonwa7, i-10-12, kunye ne-lymphopenia kunye ne-T cell subsets ezingaqhelekanga zifunyenwe kwizigulane ezigula kakhulu.13, 14 Kuxelwe ukuba umlinganiselo we-neutrophils kwi-lymphocytes uye waba luphawu oluluncedo lokuhlukanisa amaqhuqhuva anobungozi kunye ne-benign ye-thyroid kwiklinikhi.I-15 NLR inokunceda ukwahlula izigulana ezinezilonda ezizilonda esiswini kulawulo olusempilweni.I-16 Kwakhona idlala indima kwi-thyroiditis kwaye ihambelana nohlobo lwe-2 yeswekile.I-17, i-18 RDW ngumqondiso we-erythrocytosis.Izifundo ziye zafumanisa ukuba kunceda ukwahlula amaqhuqhuva e-thyroid, ukuxilonga i-rheumatoid arthritis, isifo se-lumbar disc, kunye ne-thyroiditis.I-19-21 CRP yi-predictor yendalo yonke yokuvuvukala kwaye ifundwe kwiimeko ezininzi.22 Kutshanje kufunyaniswe ukuba i-NLR, i-RDW kunye ne-CRP nazo zibandakanyeka kwi-COVID-19 kwaye zidlala indima ebalulekileyo ekufunyanisweni nasekuxilongweni kwesi sifo.11, 14, 23-25 Ngoko ke, iziphumo zovavanyo lwebhubhoratri zibalulekile ukuvavanya imeko yesigulane kunye nokwenza izigqibo zonyango.Siphinde sahlalutya iparamitha zaselabhoratri zabaguli abangama-52 be-COVID-19 ababelaliswe kwizibhedlele ezichongiweyo eMzantsi China ngokonyango lwabo lwangaphambili kunye nasemva konyango, ubukhali, kunye nobudala, ukuqonda ngakumbi utshintsho lwesi sifo kunye nokunceda ulawulo lwezonyango lwexesha elizayo. ye-COVID-19.
Olu phononongo lwenze uhlalutyo lokubuyela emva kwezigulana ezingama-52 ze-COVID-19 ezingeniswe kwisibhedlele esichongiweyo iNanning Fourth Hospital ukusuka nge-24 kaJanuwari 2020 ukuya kuMatshi 2, 2020. Phakathi kwabo, abangama-45 bebegula ngokuphakathi kwaye aba-5 bebegula kakhulu.Ngokomzekelo, ubudala buqala kwiinyanga ezi-3 ukuya kwi-85 ubudala.Ngokwesini, kwakukho amadoda angama-27 kunye nabasetyhini abangama-25.Isigulana sineempawu ezifana nomkhuhlane, ukhohlokhohlo olomileyo, ukudinwa, intloko ebuhlungu, ukuphefumla nzima, ukuxinana kweempumlo, impumlo evuzayo, umqala obuhlungu, intlungu yezihlunu, urhudo, kunye ne-myalgia.I-computed tomography yabonisa ukuba imiphunga yayinamabala okanye iglasi ephantsi, ebonisa inyumoniya.Uxilongo ngokohlelo lwesi-7 lwe-China COVID-19 yoFundo kunye neziKhokelo zoNyango.Ingqinwe ngexesha lokwenyani qPCR ukufunyaniswa kweenucleotides zentsholongwane.Ngokweendlela zokuxilonga, izigulane zahlulwa zibe ngamaqela aphakathi, anzima, kwaye anzima.Kwiimeko ezilinganiselweyo, isigulane sihlakulela umkhuhlane kunye nesifo sokuphefumula, kwaye iziphumo zemifanekiso zibonisa iipatheni ze-pneumonia.Ukuba isigulane sihlangabezana nazo naziphi na iikhrayitheriya zilandelayo, ukuxilongwa kubukhali: (a) ukuphefumula kokuphefumula (izinga lokuphefumula ≥30 ukuphefumula / iminithi);(b) ukuphumla komnwe ukugcwala kwe-oksijini yegazi ≤93%;(c) uxinzelelo lwe-oksijini ye-arterial (PO2)) / i-fraction ye-Inspiratory O2 (Fi O2) ≤300 mm Hg (1 mm Hg = 0.133 kPa).Ukuba isigulane sihlangabezana nazo naziphi na ezi zilandelayo, ukuxilongwa kunzima kakhulu: (a) ukungaphumeleli kokuphefumula okudinga ukuphefumla ngomatshini;(b) ukothuka;(c) okunye ukusilela kwamalungu kufuna unyango kwigumbi labagula kakhulu (ICU).Ngokwemiqathango engentla apha, izigulane ze-52 zafunyaniswa zigula kakhulu kwiimeko ze-2, zigula kakhulu kwiimeko ze-5, kwaye zigula ngokulinganayo kwiimeko ze-45.
Zonke izigulane, kubandakanywa izigulane ezilinganiselweyo, ezinzima kunye nezigula kakhulu, ziphathwa ngokuhambelana nezi nkqubo zilandelayo ezisisiseko: (a) unyango oluqhelekileyo lwe-adjuvant;(b) Unyango lwe-Antiviral: lopinavir/ritonavir kunye ne-α-interferon;(c) Umthamo wefomula yamayeza esintu aseTshayina unokulungelelaniswa ngokwemeko yesigulana.
Olu pho nonongo luvunyiwe yiKomiti yokuHlola yeZiko loPhando lweSibhedlele saseNanning yesine kwaye yasetyenziselwa ukuqokelela ulwazi lwesigulane.
Uhlalutyo lwe-hematology yegazi lwe-peripheral: uhlalutyo lwe-hematology oluqhelekileyo lwegazi le-peripheral lwenziwa kwi-Mindray BC-6900 i-hematology analyzer (Mindray) kunye ne-Sysmex XN 9000 i-hematology analyzer (Sysmex).I-fasting ethylenediaminetetraacetic acid (EDTA) isampuli yegazi ye-anticoagulant yaqokelelwa kusasa emva kokuba isigulane singeniswe esibhedlele.Uvavanyo oluhambelanayo phakathi kwezi zimbini zokuhlalutya igazi ziqinisekisiwe ngokuhambelana neenkqubo zokulawula umgangatho webhubhoratri.Kuhlalutyo lwe-hematology, ukubala kweeseli ezimhlophe zegazi (WBC) kunye nokwahlula, iseli ebomvu yegazi (RBC) kunye nesalathiso zifunyanwa kunye neendawo zokuchithachitha kunye ne-histograms.
I-cytometry ejikelezayo ye-T lymphocyte subpopulations: BD (Becton, Dickinson kunye neNkampani) I-FACSCalibur i-cytometer yokuhamba isetyenziselwe uhlalutyo lwe-cytometry yokuhamba ukuhlalutya i-T cell subpopulations.Hlalutya idatha ngesoftware yeMultiSET.Umlinganiselo wenziwa ngokuhambelana nemigaqo yokusebenza eqhelekileyo kunye nemiyalelo yomenzi.Sebenzisa i-EDTA anticoagulated yokuqokelela igazi ukuqokelela i-2 ml yegazi le-venous.Xuba ngobunono isampulu ngokuguqula ityhubhu yesampulu amaxesha amaninzi ukuthintela ukujiya.Emva kokuba isampuli iqokelelwe, ithunyelwa kwibhubhoratri kwaye ihlalutywe kwiiyure ezi-6 kwiqondo lokushisa.
Uhlalutyo lwe-Immunofluorescence: Iprotheyini ye-C-reactive (CRP) kunye neprocalcitonin (PCT) yahlaziywa ngokukhawuleza emva kokugqitywa kohlalutyo kusetyenziswa iisampuli zegazi ezihlalutywe yi-hematology, kwaye zihlalutye kwi-FS-112 immunofluorescence analyzer (Wondfo Biotech Co., LTD.) uhlalutyo.) Landela imiyalelo yomenzi kunye nemigangatho yenkqubo yelabhoratri.
Hlalutya i-serum alanine aminotransferase (ALT) kunye ne-aspartate aminotransferase (AST) kwi-HITACHI LABOSPECT008AS i-chemical analyzer (HITACHI).Ixesha leprothrombin (PT) lahlalutywa kwi-STAGO STA-R Evolution analyzer (Diagnostica Stago).
Reverse transcription quantitative polymerase chain reaction (RT-qPCR): Sebenzisa iitemplates ze-RNA ezibekwe zodwa kwi-nasopharyngeal swabs okanye ukukhutshwa kwephecana lokuphefumla elisezantsi ukwenza i-RT-qPCR ukubona i-SARS-CoV-2.I-Nucleic acids yahlulwe kwi-SSNP-2000A ye-nucleic acid yokuhlukana ngokuzenzekelayo iqonga (i-Bioperfectus Technologies).Ikiti yokufumanisa yanikezelwa yi-Sun Yat-sen University Daan Gene Co., Ltd. kunye ne-Shanghai BioGerm Medical Biotechnology Co., Ltd. Umjikelo we-thermal wenziwa kwi-ABI 7500 ye-thermal cycler (i-Applied Biosystems).Iziphumo zovavanyo lwe-nucleoside yentsholongwane zichazwa njengezilungileyo okanye ezingalunganga.
I-SPSS version 18.0 software yasetyenziselwa uhlalutyo lwedatha;Uvavanyo lwe-t-sample edibeneyo, uvavanyo oluzimeleyo lwe-t-test, okanye uvavanyo lwe-Mann-Whitney U lusetyenzisiwe, kwaye ixabiso le-P <.05 lithathwa njengento ebalulekileyo.
Izigulane ezihlanu ezigula kakhulu kunye nezigulane ezimbini ezigula kakhulu zazikhulile kunezo zikwiqela eliphakathi (69.3 vs. 40.4).Ulwazi olucacileyo lwe-5 izigulane ezigula kakhulu kunye ne-2 izigulane ezigula kakhulu ziboniswa kwiiTables 1A kunye ne-B. Izigulane ezinzima kunye nezigulana zidla ngokuphantsi kwi-T cell subsets kunye nezibalo ze-lymphocyte ezipheleleyo, kodwa inani leeseli ezimhlophe zegazi liqhelekile, ngaphandle kwezigulane. ngeeseli ezimhlophe zegazi eziphakamileyo (11.5 × 109/L).I-neutrophils kunye ne-monocytes nazo zihlala ziphezulu.I-PCT ye-serum, i-ALT, i-AST kunye ne-PT ye-2 izigulane ezigula kakhulu kunye ne-1 isigulane esigula kakhulu yayiphezulu, kwaye i-PT, ALT, AST ye-1 isigulane esigula kakhulu kunye ne-2 izigulane ezigula kakhulu zihambelana ngokufanelekileyo.Phantse zonke izigulane ze-7 zinezinga eliphezulu le-CRP.I-Eosinophils (EOS) kunye ne-basophils (BASO) zivame ukuba ziphantsi kwizigulane ezigula kakhulu kunye nezigulana ezinzulu (Itheyibhile 1A kunye ne-B).Itheyibhile 1 idwelisa inkcazo yoluhlu oluqhelekileyo lweeparamitha ze-hematological kubantu abadala baseTshayina.
Uhlalutyo lwamanani lubonise ukuba ngaphambi kokuba unyango, i-CD3 +, i-CD4 +, i-CD8 + T iiseli, i-lymphocyte iyonke, ububanzi bokusabalalisa i-RBC (RDW), i-eosinophils kunye ne-basophils yayingaphantsi kakhulu kunonyango (P = .000,. 000, .000, .012, . 04, .000 kunye .001).Izibonakaliso ezivuthayo ze-neutrophils, i-neutrophil / lymphocyte ratio (NLR) kunye ne-CRP ngaphambi kokuba unyango lube lukhulu kakhulu kunokuba emva kokonyango (P = .004, .011 kunye .017, ngokulandelanayo).I-Hb kunye ne-RBC yehla kakhulu emva kwonyango (P = .032, .026).I-PLT yanda emva kokonyango, kodwa yayingabalulekanga (P = .183) (Itheyibhile 2).
I-T cell subsets (CD3 +, CD4 +, CD8 +), i-lymphocytes iyonke kunye ne-basophils yezigulane ezinzima kunye nezigulana ziphantsi kakhulu kunezo zezigulane ezimodareyitha (P = .025, 0.048, 0.027, 0.006 kunye .046).Amanqanaba e-neutrophils, i-NLR, i-PCT kunye ne-CRP kwizigulane ezinzima kunye nezigulayo ziphezulu kakhulu kunezo zigulana ezilinganiselweyo (P = .005, .002, .049 kunye .002, ngokulandelanayo).Izigulane ezinobunzima kunye nezigulayo zine-PLT ephantsi kunezigulane ezimodareyitha;nangona kunjalo, umahluko wawungabalulekanga ngokwezibalo (iThebhile 3).
I-CD3 +, i-CD8 +, i-lymphocytes iyonke, iiplatelet, kunye ne-basophils yezigulane ezingaphezulu kweminyaka engama-50 ubudala zaziphantsi kakhulu kunezo zezigulane ezingaphantsi kweminyaka engama-50 ubudala (P = .049, 0.018, 0.019, 0.010 kunye .039, ngokulandelanayo), ngelixa abo bangaphezulu I-50 iminyaka yezigulane ze-neutrophils, i-NLR ratio, amanqanaba e-CRP kunye ne-RDW yayiphezulu kakhulu kunezo zezigulane ezingaphantsi kweminyaka eyi-50 ubudala (P = .0191, 0.015, 0.009, kunye .010, ngokulandelanayo) (Itheyibhile 4).
I-COVID-19 ibangelwa lusulelo lwe-coronavirus ye-SARS-CoV-2, eyaqala ukuvela e-Wuhan, e-China ngoDisemba ka-2019. Uqhambuko lwe-SARS-CoV-2 lwasasazeka ngokukhawuleza emva koko lwakhokelela kubhubhani wehlabathi.I-1-3 Ngenxa yolwazi oluncinci lwe-epidemiology kunye ne-pathology yentsholongwane, izinga lokufa ekuqaleni kokuqhambuka liphezulu.Nangona kungekho machiza okuthomalalisa iintsholongwane, ulawulo olulandelelweyo kunye nonyango lwe-COVID-19 luphuculwe kakhulu.Oku kuyinyani ngakumbi e-China xa unyango lwe-adjuvant ludityaniswe namayeza emveli aseTshayina ukunyanga iimeko zakwangoko kunye neziphakathi.Izigulana ezingama-26 ze-COVID-19 zixhamle ekuqondeni ngcono utshintsho lwe-pathological kunye neeparamitha zelebhu yesi sifo.isifo.Ukususela ngoko, izinga lokufa liye lehla.Kule ngxelo, akukho kufa phakathi kwamatyala angama-52 ahlalutywayo, kubandakanywa izigulane ezi-7 ezinzima kunye nezigula kakhulu (Itheyibhile 1A kunye ne-B).
Uqwalaselo lwezonyango lufumanise ukuba uninzi lwezigulana ezine-COVID-19 ziye zanciphisa i-lymphocytes kunye ne-T cell subpopulations, ezinxulumene nobuzaza besi sifo.I-13, i-27 kule ngxelo, kwafunyaniswa ukuba i-CD3 +, i-CD4 +, i-CD8 + T iiseli, i-lymphocytes iyonke, i-RDW ngaphambi kokuba unyango, i-eosinophils kunye ne-basophils ziphantsi kakhulu emva kokuba unyango (P = .000, .000, .000, .012, .04, .000 kunye .001).Iziphumo zethu ziyafana neengxelo zangaphambili.Ezi ngxelo zinokubaluleka kwezonyango ekubekeni iliso kubukhali be-COVID-19.8, 13, 23-25, 27, ngelixa iimpawu zokukrala kweeneutrophils, neutrophils/lymphocyte ratio (NLR ) kunye ne-CRP emva konyango lwangaphambili kunonyango (P = .004, . 011 kunye .017, ngokulandelelanayo), eziye zaqatshelwa kwaye zaxelwa ngaphambili kwizigulana ze-COVID-19.Ke ngoko, ezi parameters zithathwa njengezalathi eziluncedo kunyango lwe-COVID-19.8.Emva kokonyango, i-hemoglobin ye-11 kunye neeseli ezibomvu zegazi zancitshiswa kakhulu (P = .032, 0.026), ebonisa ukuba isigulane sine-anemia ngexesha lonyango.Ukunyuka kwe-PLT kwabonwa emva kokunyanga, kodwa kwakungabalulekanga (P = .183) (Itheyibhile 2).Ukuncipha kwe-lymphocytes kunye ne-T cell subpopulations kucatshangelwa ukuba kuhambelana nokuchithwa kweeseli kunye ne-apoptosis xa ziqokelela kwiindawo ezivuthayo ezilwa nentsholongwane.Okanye, kusenokwenzeka ukuba zidliwe kukukhuselwa okugqithisileyo kwee-cytokines kunye neeproteni ezivuthayo.8, 14, 27-30 Ukuba i-lymphocyte kunye ne-T cell subsets ziphantsi ngokuqhubekayo kwaye umlinganiselo we-CD4 +/CD8+ uphezulu, ukuxilongwa kubi.29 Ekuqwalaseleni kwethu, i-lymphocytes kunye ne-T cell subsets zafunyanwa emva kokonyango, kwaye zonke iimeko ze-52 zaphiliswa (Itheyibhile 1).Amanqanaba aphezulu e-neutrophils, i-NLR, kunye ne-CRP yabonwa ngaphambi kokuba unyango, kwaye emva koko yehla kakhulu emva kokonyango (P = .004, .011, kunye .017, ngokulandelanayo) (Itheyibhile 2).Umsebenzi we-T cell subsets kwintsholongwane kunye nokuphendula komzimba kuye kwaxelwa ngaphambili.29, 31-34
Njengoko inani lezigulane ezinzima kunye nezigulana zincinci kakhulu, asizange senze uhlalutyo lwamanani kwiiparitha phakathi kwezigulane ezinzima kunye nezigulana kunye nezigulane ezimodareyitha.I-T cell subsets (CD3+, CD4+, CD8+) kunye ne-lymphocyte iyonke yezigulane ezinobunzima kunye nezigula kakhulu ziphantsi kakhulu kunezo zezigulane ezimodareyitha.Amanqanaba e-neutrophils, i-NLR, i-PCT, kunye ne-CRP kwizigulane ezinzima kunye nezigulayo ziphezulu kakhulu kunezo zigulana ezilinganiselweyo (P = .005, .002, .049, kunye .002, ngokulandelanayo) (Itheyibhile 3).Utshintsho kwiparamitha zelebhu zinxulumene nobungqongqo be-COVID-19.35.36 Unobangela we-basophilia awucacanga;oku kunokuba ngenxa yokusetyenziswa kokutya ngelixa kusilwa intsholongwane kwindawo yosulelo olufana ne-lymphocytes.35 Uphononongo lufumanise ukuba izigulana ezine-COVID-19 eqatha nazo ziye zanciphisa iieosinophils;I-14 Nangona kunjalo, idatha yethu ayizange ibonise ukuba le nto ingenzeka ngenxa yenani elincinci leemeko ezinzima kunye nezibalulekileyo ezibonwa kwisifundo.
Kuyathakazelisa ukuba sifumene ukuba kwizigulane ezinzima kunye nezigulayo, kukho ulungelelwaniso oluhle phakathi kwe-PT, ALT, kunye ne-AST, ebonisa ukuba umonakalo wamalungu amaninzi wenzeke ekuhlaselweni kwentsholongwane, njengoko kukhankanyiwe kwezinye izinto.37 Ke ngoko, inokuba ziiparamitha ezintsha eziluncedo zokuvavanya impendulo kunye nengqikelelo yonyango lwe-COVID-19.
Uhlalutyo olongezelelweyo lubonise ukuba i-CD3 +, i-CD8 +, i-lymphocytes iyonke, iiplatelet kunye ne-basophils yezigulane ezingaphezu kweminyaka engama-50 ubudala zaziphantsi kakhulu kunezo zezigulane ezingaphantsi kweminyaka engama-50 ubudala (P = P = .049, .018, .019, .010 kunye. 039, ngokulandelanayo), ngelixa amanqanaba e-neutrophils, i-NLR, i-CRP, kunye ne-RBC RDW kwizigulane ezingaphezu kweminyaka engama-50 ubudala zaziphezulu kakhulu kunezo zezigulane ezingaphantsi kweminyaka eyi-50 ubudala (P = .0191, 0.015, 0.009, kunye .010 , ngokulandelelanayo) (Itheyibhile 4).Ezi ziphumo ziyafana neengxelo zangaphambili.14, 28, 29, 38-41 Ukuncipha kwi-T cell subpopulations kunye ne-CD4 +/CD8 + T cell ratios ephezulu inxulumene nobunzima besifo;iimeko zabantu abadala zithande ukuba nzima ngakumbi;ngoko ke, i-lymphocyte ezininzi ziya kudliwa kwimpendulo yomzimba okanye yonakele kakhulu.Ngokunjalo, iRBC RDW ephezulu ibonisa ukuba ezi zigulana ziye zaphuhla i-anemia.
Iziphumo zethu zophando zikwaqinisekisa ukuba iiparamitha ze-hematological zibaluleke kakhulu ekuqondeni ngcono utshintsho lwezonyango lwezigulane ze-COVID-19 kunye nokuphucula isikhokelo sonyango kunye ne-prognosis.
U-Liang Juanying kunye noNong Shaoyun baqokelele idatha kunye nolwazi lweklinikhi;UJiang Liejun kunye noChi Xiaowei benza uhlalutyo lwedatha;UDewu Bi, uJun Cao, uLida Mo, kunye noXiaolu Luo benza uhlalutyo lwesiqhelo;U-Huang Huayi wayejongene nokukhulelwa nokubhala.
Nceda ujonge i-imeyile yakho ngemiyalelo yokusetha kwakhona igama lokugqitha lakho.Ukuba awufumani imeyile kwimizuzu eli-10, idilesi yakho ye-imeyile ayinakubhaliswa kwaye unokufuna ukwenza i-akhawunti entsha yeThala leeNcwadi ye-Intanethi ye-Wiley.
Ukuba idilesi ihambelana neakhawunti ekhoyo, uya kufumana i-imeyile enemiyalelo yokufumana igama lomsebenzisi
Ixesha lokuposa: Jul-22-2021