Iziphumo zilungile kubaphuhlisi bovavanyo lwe-antigen, ababone imfuno yehla emva kokuba isitofu sokugonya siqalisiwe.
Uphononongo oluncinci oluxhaswa ngemali ngamaZiko eSizwe ezeMpilo (NIS) lufumanise ukuba uvavanyo lwe-Covid-19 lateral flow (LFT) lusebenza njengovavanyo lwe-polymerase chain reaction (PCR) ekubhaqeni usulelo lwe-SARS-CoV-2.Yenziwa rhoqo ngeentsuku ezintathu Uvavanyo olunye.
Uvavanyo lwe-PCR lujongwa njengomgangatho wegolide wokufumanisa usulelo lwe-Covid-19, kodwa ukusetyenziswa kwazo ngokubanzi njengezixhobo zokuhlola kulinganiselwe kuba kufuneka ziqwalaselwe elabhoratri kwaye iziphumo zinokuthatha iintsuku ezininzi ukufikelela kwizigulana.
Ngokwahlukileyo, iLFT inokubonelela ngeziphumo kwimizuzu nje eli-15, kwaye abasebenzisi akufuneki nokuba balishiye ikhaya.
Abaphandi abanxulumana ne-NIH Diagnostic Rapid Acceleration Programme baxele iziphumo zabantu abangama-43 abosulelwe yi-Covid-19.Abathathi-nxaxheba bebesuka kwiYunivesithi yase-Illinois e-Urbana-Champaign (UIUC) SHIELD Illinois Covid-19 inkqubo yokuhlola.Baye bavavanya ukuba banayo okanye babenxibelelana ngokusondeleyo nabantu abavavanywe ukuba banayo.
Abathathi-nxaxheba bamkelwa kwiintsuku ezimbalwa zokuvezwa yintsholongwane, kwaye iziphumo zovavanyo zazingalunganga kwiintsuku ezisi-7 ngaphambi kokubhaliswa.
Bonke banikezela ngeesampulu zamathe kunye neentlobo ezimbini ze-swabs zempumlo kwiintsuku ze-14 ezilandelelanayo, eziye zacutshungulwa yi-PCR, LFT, kunye nenkcubeko yentsholongwane ephilayo.
Inkcubeko yentsholongwane yinkqubo yokusebenza kakhulu kunye neendleko ezinkulu engasetyenziswa kuvavanyo lwesiqhelo lwe-Covid-19, kodwa inceda ukumisela kakhulu ubume bentsholongwane kwisampulu.Oku kunokunceda abaphandi baqikelele ukuqala kunye nexesha losulelo lwe-Covid-19.
UChristopher Brooke, uNjingalwazi weMolecular and Cell Biology kwi-UIUC, uthe: “Uninzi lovavanyo lufumanisa imathiriyeli yemfuza enxulumene nentsholongwane, kodwa oku akuthethi ukuba kukho intsholongwane ephilayo.Ekuphela kwendlela yokubona ukuba kukho intsholongwane ephilayo, eyosulelayo kukwenza ukuzimisela okanye inkcubeko. ”
Emva koko, abaphandi bathelekisa iindlela ezintathu zokubona intsholongwane ye-Covid-19-ukufunyanwa kwe-PCR yamathe, ukufunyanwa kwe-PCR yeesampulu zeempumlo, kunye nokufunyanwa kwe-antigen ekhawulezileyo ye-Covid-19 yeesampulu zempumlo.
Iziphumo zesampulu yamathe zenziwa luvavanyo lwe-PCR olugunyazisiweyo olusekwe kumathe aphuhliswe yi-UIUC, ebizwa ngokuba yi-covidSHIELD, enokuvelisa iziphumo emva kweeyure ezimalunga ne-12.Uvavanyo lwe-PCR olwahlukileyo kusetyenziswa isixhobo se-Abbott Alinity sisetyenziselwa ukufumana iziphumo kwi-swabs yeempumlo.
Ukufunyaniswa kwe-antigen ngokukhawuleza kwenziwa kusetyenziswa i-Quidel Sofia SARS antigen fluorescence immunoassay, LFT, egunyazisiweyo yokhathalelo olukhawulezileyo kwaye inokuvelisa iziphumo emva kwemizuzu eyi-15.
Emva koko, abaphandi babala ubuntununtunu bendlela nganye ekufumaneni i-SARS-CoV-2, kwaye balinganisa ubukho bentsholongwane ephilayo kwiiveki ezimbini zosulelo lokuqala.
Bafumanise ukuba uvavanyo lwe-PCR lunovakalelo ngakumbi kunovavanyo olukhawulezayo lwe-antigen ye-Covid-19 xa kuvavanywa intsholongwane ngaphambi kwexesha losulelo, kodwa bachaza ukuba iziphumo ze-PCR zinokuthatha iintsuku ezininzi ukuba zibuyiselwe kumntu ovavanywayo.
Abaphandi babale ubuntununtunu bovavanyo ngokusekwe kuvavanyo rhoqo kwaye bafumanisa ukuba ubuntununtunu bokubona usulelo bungaphezulu kwe-98% xa uvavanyo lwenziwa rhoqo ngeentsuku ezintathu, nokuba luvavanyo olukhawulezayo lwe-antigen ye-Covid-19 okanye uvavanyo lwePCR.
Xa bevavanya ukufunyanwa rhoqo ngeveki, uvakalelo lokubhaqwa kwe-PCR kumngxunya weempumlo kunye namathe kwakusephezulu, malunga ne-98%, kodwa ubuntununtunu bokufunyanwa kwe-antigen buye kwehla ukuya kuma-80%.
Iziphumo zibonisa ukuba ukusebenzisa uvavanyo olukhawulezayo lwe-antigen ye-Covid-19 ubuncinci kabini ngeveki kuvavanyo lwe-Covid-19 kunomsebenzi othelekisekayo kuvavanyo lwe-PCR kwaye kwandisa amathuba okufumana umntu osulelekileyo kumanqanaba okuqala esi sifo.
Ezi ziphumo ziya kwamkelwa ngabaphuhlisi abakhawulezayo bovavanyo lwe-antigen, abathe kutshanje baxela ukuba imfuno yovavanyo lwe-Covid-19 yehlile ngenxa yokwaziswa kwesitofu sokugonya.
Zombini intengiso ye-BD kunye ne-Quidel kwimivuzo yamva nje ibisezantsi kunolindelo lwabahlalutyi, kwaye emva kokuba imfuno yovavanyo lwe-Covid-19 yehle kakhulu, u-Abbott wehlisa imbonakalo yakhe ka-2021.
Ngexesha lo bhubhani, abezonyango abavumelani nokusebenza kwe-LFT, ngakumbi kwiinkqubo zovavanyo olukhulu, njengoko zidla ngokuqhuba kakubi ekufumaneni usulelo olungenazimpawu.
Uphononongo olupapashwe ngamaZiko e-US oLawulo lweSifo kunye noThintelo ngoJanuwari lubonise ukuba uvavanyo luka-Abbott olukhawulezileyo olukhawulezileyo i-BinaxNOW inokuphosa phantse isibini kwisithathu sosulelo lwe-asymptomatic.
Kwangelo xesha, uvavanyo lwe-Innova olusetyenziswa e-UK lubonise ukuba ubuntununtunu kwizigulana ezineempawu ze-Covid-19 zazingama-58% kuphela, ngelixa idatha yokulinga elinganiselweyo ibonise ukuba ubuntununtunu be-asymptomatic yayingama-40 kuphela.
Ixesha lokuposa: Jul-05-2021